Yes. The manual will provide guidelines in this regard. The 2-bay 583’s (583E and the original 583S) have square openings that are intentionally designed to allow users access to the 12AX7 and replace with other like tubes for additional flexibility. Generally speaking, it’s the input tubes (the 12AX7s or 12DW7s) that would be replaced if you are looking to alter the sound of the amplifier. The 992’s output tubes require a critical balancing step so, for that reason we don’t recommend messing with these. In any case, if there’s ever a question related to swapping out tubes PLEASE give us a call.